Prednisolon vermindert pijn bij handartrosjanuari 29, 2020
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A short course of a potent dose of prednisolone safely reduced finger pain and local joint inflammation in patients with hand osteoarthritis, a trial in The Lancet reported.
The study’s 92 participants were randomly assigned to receive 10 mg of oral prednisolone or placebo once a day for 6 weeks, followed by 2 weeks of tapering, and then a 6-week follow-up without study medication. At the start of the trial, participants had signs of inflammation in their finger joints and most had a pain flare-up during a 48-hour washout of nonsteroidal anti-inflammatory drugs.
The mean change in finger pain between baseline and week 6 on the 100-mm visual analog scale was –21.5 in the prednisolone group and –5.2 in the placebo group, a statistically significant difference. Five serious adverse events occurred: a myocardial infarction in the prednisolone group and 4 events in the placebo group.
Based on the large effect size, this new short-term treatment option is more effective for reducing hand osteoarthritis pain and improving function in patients with joint inflammation than existing therapies, according to the authors.